GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs896854 | 1 | rs7003387 | chr8:95961979 | INTS8 | chr8:95835534-95892720:+ | 0.16 | 3.87 | 0.000123 | Type 2 diabetes |
| THCA | cis | rs13256369 | 1 | rs7004438 | chr8:8574379 | SGK223 | chr8:8175259-8239257:- | -0.3 | -5.55 | 4.75E-8 | Obesity-related traits |
| THCA | cis | rs2129782 | 1 | rs7004757 | chr8:89446178 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs7005380 | 1 | rs7005380 | chr8:120953873 | DSCC1 | chr8:120846182-120868170:- | -0.28 | -5.74 | 1.68E-8 | Interstitial lung disease |
| THCA | cis | rs1027730 | 1 | rs7006316 | chr8:94082090 | C8orf83 | chr8:93895865-94029901:- | 0.2 | 3.37 | 0.000806 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2129782 | 1 | rs7006506 | chr8:89426102 | MMP16 | chr8:89049462-89339717:- | 0.32 | 5.16 | 3.61E-7 | Electrodermal activity |
| THCA | cis | rs6982751 | 1 | rs7006612 | chr8:10813636 | CTSB | chr8:11700036-11725646:- | 0.22 | 3.5 | 0.000501 | Asthma and hay fever |
| THCA | cis | rs1027730 | 1 | rs7006842 | chr8:94082345 | C8orf83 | chr8:93895865-94029901:- | 0.21 | 3.47 | 0.000575 | Attention deficit hyperactivity disorder |
| THCA | cis | rs7017914 | 1 | rs7007450 | chr8:71640269 | XKR9 | chr8:71581600-71648176:+ | 1.06 | 27.41 | 4.36E-100 | Bone mineral density |
| THCA | cis | rs2129782 | 1 | rs7008219 | chr8:89451970 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs7818688 | 1 | rs7008542 | chr8:96027863 | C8orf38 | chr8:95908040-96088396:+ | -0.25 | -4.26 | 2.48E-5 | Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia |
| THCA | cis | rs2645424 | 1 | rs7009302 | chr8:11685981 | CTSB | chr8:11700036-11725646:- | -0.17 | -3.97 | 8.43E-5 | Non-alcoholic fatty liver disease histology (lobular);Non-alcoholic fatty liver disease histology (other) |
| THCA | cis | rs7009516 | 1 | rs7009516 | chr8:24208847 | ADAMDEC1 | chr8:24241798-24263526:+ | 0.18 | 5.31 | 1.7E-7 | Hair greying |
| THCA | cis | rs1027730 | 1 | rs7011959 | chr8:94072252 | C8orf83 | chr8:93895865-94029901:- | 0.28 | 4.45 | 1.07E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs7012814 | 1 | rs7012814 | chr8:9173358 | SGK223 | chr8:8175259-8239257:- | -0.23 | -4.27 | 2.36E-5 | Fibrinogen levels |